Trifluoroacetic acid → HCID 86624960, compound

HRID 1041849Notes

Reaction equation

HRID 1041849 reaction equation
[F:1][C:2]([F:8])([F:7])[S:3]([O-:6])(=[O:5])=[O:4].[F:9][C:10]1[CH:15]=[C:14]([C:16]([O:18]C)=[O:17])[CH:13]=[CH:12][C:11]=1[N+:20]([CH3:23])([CH3:22])[CH3:21].FC(F)(F)C(O)=O>O>[F:1][C:2]([F:8])([F:7])[S:3]([O-:6])(=[O:5])=[O:4].[C:16]([C:14]1[CH:13]=[CH:12][C:11]([N+:20]([CH3:22])([CH3:21])[CH3:23])=[C:10]([F:9])[CH:15]=1)([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86624959HCID 86624959, compound

Product 1

HCID 86624960HCID 86624960, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 4.00 g (11.1 mmol) 10, 96 ml dest. water and 96 ml trifluoroacetic acid was refluxed for 2 days. The reaction mixture was evaporated, dried by use of oil pump vacuum over night and treated with diethyl ether. The resulting solid was filtered, washed extensively with diethyl ether and dried by oil pump vacuum. The solid crude product 11 was obtained in 92% yield (3.54 g, 10.2 mmol) and crude compound 11 was used for the next step without purification.

Workup

  1. customThe reaction mixture was evaporated
  2. customdried by use of oil pump vacuum over night
  3. additiontreated with diethyl ether
  4. filtrationThe resulting solid was filtered
  5. washwashed extensively with diethyl ether
  6. customdried by oil pump vacuum

Sources & evidence

ORD record
ord-9d99bbb32d5942759ea64d8eb7f8a87e
Source dataset
uspto-grants-2013_10
Patent number
US08557776B2

Reaction notes

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