反应详情

A solution of 0.5 g (1.32 mmol) 18b, 12 ml dest. water and 12 ml trifluoroacetic acid was refluxed for 2 days. The reaction mixture was evaporated, dried by use of oil pump vacuum over night and treated with diethyl ether. The resulting solid was filtered, washed extensively with diethyl ether and dried by oil pump vacuum. The solid crude product 18c was obtained in 98% yield (471 mg, 1.3 mmol) and crude compound 18c was used for the next step without purification.

1. customThe reaction mixture was evaporated
2. customdried by use of oil pump vacuum over night
3. additiontreated with diethyl ether
4. filtrationThe resulting solid was filtered
5. washwashed extensively with diethyl ether
6. customdried by oil pump vacuum