Methyl 2,3-Dihydroxybenzoate → Methyl 2-hydroxy-3-(m-tolyloxy)benzoate

HRID 1041892Notes

Reaction equation

HRID 1041892 reaction equation
[OH:1][C:2]1[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:13]1([CH3:22])[CH:18]=[CH:17][CH:16]=[C:15](B(O)O)[CH:14]=1>>[OH:1][C:2]1[C:11]([O:12][C:15]2[CH:14]=[C:13]([CH3:22])[CH:18]=[CH:17][CH:16]=2)=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Participants

3

Reactant 2

HCID 75484Methyl 2,3-DihydroxybenzoateHCID 27339503-Tolylboronic acid

Product 1

HCID 70926721Methyl 2-hydroxy-3-(m-tolyloxy)benzoateYield 36.5%

Procedure

According to the method of (Example 99) <Step 1>, from methyl 2,3-dihydroxybenzoate (1 g) and m-tolyl boronic acid (0.97 g) that are commercially available, the subject compound (0.56 g) was obtained as pale yellow oil.

Sources & evidence

ORD record
ord-4fd9a48650e3414992bdd044b5c1fb59
Source dataset
uspto-grants-2013_10
Patent number
US08557766B2

Reaction notes

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