4-Cyano-2-fluorobenzoic acid → Methyl 4-cyano-2-fluorobenzoate

HRID 1041918Notes

Reaction equation

HRID 1041918 reaction equation
O1CCOC[CH2:2]1.Cl.[C:8]([C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[C:12]([F:19])[CH:11]=1)#[N:9]>CO>[C:8]([C:10]1[CH:18]=[CH:17][C:13]([C:14]([O:16][CH3:2])=[O:15])=[C:12]([F:19])[CH:11]=1)#[N:9]

Participants

4

Reactant 2

HCID 5906594-Cyano-2-fluorobenzoic acidHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 15278726Methyl 4-cyano-2-fluorobenzoate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

A 4 M hydrochloric acid dioxane solution (70.0 mL, 280 mmol) was added to a methanol (70.0 mL) solution of 4-cyano-2-fluorobenzoic acid (10.0 g, 60.6 mmol), and the mixture was stirred for one hour at 70° C. The reaction mixture was cooled to room temperature, and then the solvent was distilled off under reduced pressure. Thus, a crude product of the title compound was obtained.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-1b4b39fe98394fe68018db60a4762390
Source dataset
uspto-grants-2013_10
Patent number
US08557802B2

Reaction notes

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