4-Cyano-2-fluorobenzoic acid → Methyl 4-cyano-2-fluorobenzoate

Participants

Reaction Conditions

Reaction Steps

A 4 M hydrochloric acid dioxane solution (70.0 mL, 280 mmol) was added to a methanol (70.0 mL) solution of 4-cyano-2-fluorobenzoic acid (10.0 g, 60.6 mmol), and the mixture was stirred for one hour at 70° C. The reaction mixture was cooled to room temperature, and then the solvent was distilled off under reduced pressure. Thus, a crude product of the title compound was obtained.

Provenance & Evidence