HCID 59609972, compound → HCID 59609986, compound

HRID 1042048Notes

Reaction equation

HRID 1042048 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[O:12][C:11]3[C:13]([C:16]4[N:17](C(OC(C)(C)C)=O)[CH:18]=[CH:19][CH:20]=4)=[CH:14][S:15][C:10]=3[C:9](=[O:28])[CH:8]=2)[CH2:3][CH2:2]1>Cl>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[O:12][C:11]3[C:13]([C:16]4[NH:17][CH:18]=[CH:19][CH:20]=4)=[CH:14][S:15][C:10]=3[C:9](=[O:28])[CH:8]=2)[CH2:5][CH2:6]1

Participants

3

Reactant 1

HCID 59609972HCID 59609972, compound

Product 1

HCID 59609986HCID 59609986, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A 20 mL vial was charged with a magnetic stirring bar, tert-butyl 2-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)-1H-pyrrole-1-carboxylate (94) (50 mg, 124 μmol), and hydrochloric acid (4.0 M in dioxane, 10 mL). The reaction mixture was magnetically stirred overnight at room temperature, concentrated in vacuo, and purified via reverse phase high-pressure liquid chromatography to give 5-morpholino-3-(1H-pyrrol-2-yl)-7H-thieno[3,2-b]pyran-7-one (97).

Workup

  1. additionA 20 mL vial was charged with a magnetic stirring bar
  2. concentrationconcentrated in vacuo
  3. custompurified via reverse phase high-pressure liquid chromatography

Sources & evidence

ORD record
ord-c13fa4f36cd345b691c862098aef23d4
Source dataset
uspto-grants-2013_10
Patent number
US08557807B2

Reaction notes

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