Potassium Cation → methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3H-imidazo[4,5-c]pyridin-3-yl]-3-{1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxylate

HRID 104233Notes

Reaction equation

HRID 104233 reaction equation
[Br:63][CH:64]([CH3:65])[c:66]1[c:67]([C:72]([F:73])([F:74])[F:75])[cH:68][cH:69][cH:70][cH:71]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][c:10]2[c:11]([cH:12][n:13]1)[n:14](-[c:17]1[cH:18][c:19]([OH:26])[c:20]([C:22](=[O:23])[O:24][CH3:25])[s:21]1)[cH:15][n:16]2)([CH3:27])[CH3:28].[C:29]([Si:30]([CH3:31])([CH3:32])[O:33][CH2:34][c:35]1[n:36][cH:37][c:38]2[n:39][cH:40][n:41](-[c:42]3[s:43][c:44]([C:45]([O:46][CH3:47])=[O:48])[c:49]([OH:50])[cH:51]3)[c:52]2[cH:53]1)([CH3:54])([CH3:55])[CH3:56].[CH3:76][N:77]([CH3:78])[CH:79]=[O:80].[K+:57].[K+:58].[O-:59][C:60]([O-:61])=[O:62]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][c:10]2[c:11]([cH:12][n:13]1)[n:14](-[c:17]1[cH:18][c:19]([O:26][CH:64]([CH3:65])[c:66]3[c:67]([C:72]([F:73])([F:74])[F:75])[cH:68][cH:69][cH:70][cH:71]3)[c:20]([C:22](=[O:23])[O:24][CH3:25])[s:21]1)[cH:15][n:16]2)([CH3:27])[CH3:28]

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 27756211-(1-Bromoethyl)-2-(trifluoromethyl)benzeneHCID 68766004methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3H-imidazo[4,5-c]pyridin-3-yl]-3-hydroxythiophene-2-carboxylateHCID 68766707methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate

Product 1

HCID 68770304methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3H-imidazo[4,5-c]pyridin-3-yl]-3-{1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxylate

Sources & evidence

ORD record
ord-38bfae9ff97c45139b76ca0643ca4ed6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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