反应详情

2-Cyano 4-methylpyridine in MeOH (35 ml) and concentrated HCl (1 ml) was stirred under a H2 balloon for 14 hours. The reaction mixture was filtered and concentrated. The pH was adjusted to 12 by the addition of aq sodium hydroxide. The resulting reaction mixture was extracted with dichloromethane several times. Concentration of the solvent gave the crude title compound, which was used in the next step without further purification.

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated
3. additionThe pH was adjusted to 12 by the addition of aq sodium hydroxide
4. customThe resulting reaction mixture
5. extractionwas extracted with dichloromethane several times