反应详情

温度

60 °C

32 g of tert-Butyl 4-cyano-3-hydroxy-2,2-dimethyl-2,5-dihydro-1H-pyrrole-1-carboxylate (0.134 mol) were added to 430 ml of absolute ethanol. To this solution, 9 ml (0.18 mol) of hydrazine hydrate were added, followed by 12 ml of glacial AcOH (1.5 eq); The mixture was stirred at 60° C. for 48 hours, the ethanol was removed, the residue was taken up with 400 ml of sodium hydrogencarbonate solution, and extracted several times with ethyl acetate up to total extraction of the desired product. The organic phases were dried and evaporated. After purification by flash chromatography (eluent: CHCl3/EtOH 97/3) and trituration with a mixture of hexane/ethyl acetate 9/1, 25 g of title compound were obtained. Total yield 30.5 g (yield: 88%)

1. customthe ethanol was removed
2. extractionextracted several times with ethyl acetate
3. extractionup to total extraction of the desired product
4. customThe organic phases were dried
5. customevaporated
6. customAfter purification by flash chromatography (eluent: CHCl3/EtOH 97/3) and trituration
7. additionwith a mixture of hexane/ethyl acetate 9/1