2-Propoxy-4-trifluoromethyl-benzoic acid propyl ester → 2-Propoxy-4-(trifluoromethyl)benzoic acid

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Reaction Steps

2-Propoxy-4-trifluoromethyl-benzoic acid propyl ester (957 mg, 3.44 mmol) was reacted with 1N LiOH (10 ml) at room temperature for 4 hrs. The reaction solvent was removed in vacuo. Water (30 ml) was added to the resulting residue, which was neutralized with 1 N aqueous HCl solution. The aqueous mixture was extracted with ethylacetate (30 ml×3). A combined organic layer was dried over MgSO4, and concentrated in vacuo to yield quantitatively title compound.

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