反应详情

2-Propoxy-4-trifluoromethyl-benzoic acid propyl ester (957 mg, 3.44 mmol) was reacted with 1N LiOH (10 ml) at room temperature for 4 hrs. The reaction solvent was removed in vacuo. Water (30 ml) was added to the resulting residue, which was neutralized with 1 N aqueous HCl solution. The aqueous mixture was extracted with ethylacetate (30 ml×3). A combined organic layer was dried over MgSO4, and concentrated in vacuo to yield quantitatively title compound.

1. customThe reaction solvent was removed in vacuo
2. additionWater (30 ml) was added to the resulting residue, which
3. extractionThe aqueous mixture was extracted with ethylacetate (30 ml×3)
4. dry with materialA combined organic layer was dried over MgSO4
5. concentrationconcentrated in vacuo