反应详情

N-Methoxy-N-methyl-2-propoxy-4-trifluoromethyl-benzamide (277 mg) in THF was reacted with 1 M LAH (1 ml) on −50° C. for 1 hr. The reaction mixture was quenched by adding aqueous potassium hydrogen sulfate (5 ml). The mixture was stirred for 30 min. The reaction solvent was removed in vacuo. Water (30 ml) was added to the resulting residue, which was extracted with ethyl acetate (30 ml×3). The combined organic layer was washed with brine (30 ml) and dried over MgSO4 and concentrated in vacuo to yield title compound (232 mg, 100%).

1. customThe reaction mixture was quenched
2. additionby adding aqueous potassium hydrogen sulfate (5 ml)
3. customThe reaction solvent was removed in vacuo
4. additionWater (30 ml) was added to the resulting residue, which
5. extractionwas extracted with ethyl acetate (30 ml×3)
6. washThe combined organic layer was washed with brine (30 ml)
7. dry with materialdried over MgSO4
8. concentrationconcentrated in vacuo