HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-(2-Ethoxy-4-trifluoromethyl-phenyl)-acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 3-(2-Ethoxy-4-trifluoromethyl-phenyl)-acrylic acid methyl ester | HCID 66855439 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(2-Ethoxy-4-trifluoromethyl-phenyl)-acrylic acid | HCID 66856730 | 97.2% |
Reaction Steps
3-(2-Ethoxy-4-trifluoromethyl-phenyl)-acrylic acid methyl ester (477 mg, 1.74 mmol) was reacted with 1N LiOH (7.5 ml) in THF and CH3OH for 1.5 hrs as described above to yield title compound (440 mg, 97%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-88d746742b3348f6b04a3e6fc673175d |
| Source note | uspto-grants-2013_10 |