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HRID1042460

反应详情

EQUATION

反应方程式

HRID 1042460 的结构方程式

REACTANTS

反应物

2
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CCOc1cc(C(F)(F)F)ccc1C=CC(=O)OC
HCID66855439

未命名化合物

PRODUCTS

生成物

1
结构：CCOc1cc(C(F)(F)F)ccc1C=CC(=O)O
HCID66856730

未命名化合物

收率 97.2%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

3-(2-Ethoxy-4-trifluoromethyl-phenyl)-acrylic acid methyl ester (477 mg, 1.74 mmol) was reacted with 1N LiOH (7.5 ml) in THF and CH3OH for 1.5 hrs as described above to yield title compound (440 mg, 97%)