HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 2-butoxy-N-methoxy-N-methyl-4-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | N,O-Dimethylhydroxylamine | HCID 14232 | — |
| Reactant | 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride | HCID 2734059 | — |
| Reactant | HCID 66855761 | HCID 66855761 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-butoxy-N-methoxy-N-methyl-4-trifluoromethyl-benzamide | HCID 86649967 | 103.1% |
Reaction Steps
2-Butoxy-4-trifluoromethyl-benzoic acid (687 mg) was reacted with N,O-dimethylhydroxy amine (331 mg), NMM (0.65 ml) and DMTMM (911 mg) as described above to yield the title compound (825 mg) after column chromatography (Hex/EtOAc=7.5/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-4d0d1793ceba44db9ab3672629b06c9a |
| Source note | uspto-grants-2013_10 |