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HRID1042487

反应详情

EQUATION

反应方程式

HRID 1042487 的结构方程式

REACTANTS

反应物

4
结构：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

结构：CNOC
HCID14232

N-Methoxymethylamine

C2H7NO

结构：COc1nc(OC)nc([N+]2(C)CCOCC2)n1.[Cl-]
HCID2734059

未命名化合物

结构：CCCCOc1cc(C(F)(F)F)ccc1C(=O)O
HCID66855761

未命名化合物

PRODUCTS

生成物

1
结构：CCCCOc1cc(C(F)(F)F)ccc1C(=O)N(C)OC
HCID86649967

未命名化合物

收率 103.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

2-Butoxy-4-trifluoromethyl-benzoic acid (687 mg) was reacted with N,O-dimethylhydroxy amine (331 mg), NMM (0.65 ml) and DMTMM (911 mg) as described above to yield the title compound (825 mg) after column chromatography (Hex/EtOAc=7.5/1).