HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → 3-(2-Butoxy-4-trifluoromethyl-phenyl)-acrylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester | HCID 17453 | — |
| Reactant | 2-Butoxy-4-trifluoromethyl-benzaldehyde | HCID 86649968 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2-Butoxy-4-trifluoromethyl-phenyl)-acrylic acid methyl ester | HCID 66855719 | 90% |
Reaction Steps
2-Butoxy-4-trifluoromethyl-benzaldehyde (420 mg) was reacted with methyl (triphenylphosphoranylidene)acetate (679 mg) at 110° C. overnight as described above to yield title compound (464 mg) after column chromatography (Hex/EtOAc=20/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-b8ab6c144cec439c9035284484b64a71 |
| Source note | uspto-grants-2013_10 |