HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 3-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acid methyl ester | HCID 66855955 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acid | HCID 66857188 | 82.7% |
Reaction Steps
3-(2-sec-Butoxy-4-fluoro-phenyl)-acrylic acid methyl ester (105 mg) was reacted with 1N LiOH (5 ml) in THF and CH3OH for 2 hrs as described above to yield title compound (82 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-a01978779a544175bc7cb2aa2166718a |
| Source note | uspto-grants-2013_10 |