Lithium Hydroxide → 3-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acid

HRID 1042495Notes

Reaction equation

HRID 1042495 reaction equation
C[O:2][C:3](=[O:18])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=1[O:13][CH:14]([CH2:16][CH3:17])[CH3:15].[Li+].[OH-]>C1COCC1.CO>[CH:14]([O:13][C:7]1[CH:8]=[C:9]([F:12])[CH:10]=[CH:11][C:6]=1[CH:5]=[CH:4][C:3]([OH:18])=[O:2])([CH2:16][CH3:17])[CH3:15]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 668559553-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acid methyl ester

Product 1

HCID 668571883-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acidYield 82.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

3-(2-sec-Butoxy-4-fluoro-phenyl)-acrylic acid methyl ester (105 mg) was reacted with 1N LiOH (5 ml) in THF and CH3OH for 2 hrs as described above to yield title compound (82 mg)

Sources & evidence

ORD record
ord-a01978779a544175bc7cb2aa2166718a
Source dataset
uspto-grants-2013_10
Patent number
US08557872B2

Reaction notes

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