HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanuric chloride → Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanuric chloride | HCID 7954 | — |
| Reactant | Tert-butyl ((2r,5s,7as)-5-carbamoyl-3-oxohexahydropyrrolizin-2-yl)carbamate | HCID 90895673 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate | HCID 91321587 | — |
Reaction Steps
100 mg of tert-butyl ((2R,5S,7aS)-5-carbamoyl-3-oxohexahydropyrrolizin-2-yl)carbamate were dissolved in 2 ml of dimethylformamide, and 65 mg of cyanuric chloride were added. The mixture was stirred for 3 h, and the dimethylformamide was removed in vacuo. The residue was chromatographed on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094800B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-93eff2bf0daa450c897e724582f37625 |
| Source note | uspto-grants-2006_08 |