2-Hydroxy-4-(trifluoromethyl)benzoic acid → HCID 58111822, compound

HRID 1042504Notes

Reaction equation

HRID 1042504 reaction equation
[OH:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH:15]1([CH2:21]OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:15]1([CH2:21][O:5][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][C:9]([C:11]([F:12])([F:13])[F:14])=[CH:10][C:2]=2[O:1][CH2:4][CH:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH2:2]2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 1645782-Hydroxy-4-(trifluoromethyl)benzoic acidHCID 11807699Cyclohexylmethyl 4-methylbenzenesulfonate

Product 1

HCID 58111822HCID 58111822, compoundYield 198.2%

Procedure

2-Hydroxy-4-trifluoromethyl-benzoic acid (246 mg, 1.19 mmol) was reacted with toluene-4-sulfonic acid cyclohexylmethyl ester (640 mg, 2.34 mmol) as described above to give the title compound (470 mg, 99%) after purification by column chromatography.

Sources & evidence

ORD record
ord-a2399f00a7c0495e884d5a4d7f735aa3
Source dataset
uspto-grants-2013_10
Patent number
US08557872B2

Reaction notes

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