Pyrrole → HCID 11633205, compound

HRID 1042598Notes

Reaction equation

HRID 1042598 reaction equation
[N:1]1([C:6]2[O:10][C:9]3[C:11]([OH:17])=[C:12]([O:15][CH3:16])[CH:13]=[CH:14][C:8]=3[C:7]=2[C:18](=[O:31])[C:19]2[CH:24]=[C:23]([O:25][CH3:26])[C:22]([O:27][CH3:28])=[C:21]([O:29][CH3:30])[CH:20]=2)[CH:5]=NC=N1.N1C=[CH:35][CH:34]=[CH:33]1>>[N:1]1([C:6]2[O:10][C:9]3[C:11]([OH:17])=[C:12]([O:15][CH3:16])[CH:13]=[CH:14][C:8]=3[C:7]=2[C:18](=[O:31])[C:19]2[CH:20]=[C:21]([O:29][CH3:30])[C:22]([O:27][CH3:28])=[C:23]([O:25][CH3:26])[CH:24]=2)[CH:35]=[CH:34][CH:33]=[CH:5]1

Participants

3

Reactant 2

HCID 8027PyrroleHCID 11524689HCID 11524689, compound

Product 1

HCID 11633205HCID 11633205, compound

Procedure

This material was prepared in a similar manner as 2-(1,2,4-triazol-1-yl)-7-hydroxy-3-(3,4,5-trimethoxybenzoyl)-6-methoxy-benzo[b]furan (entry 43, Table 1), above, using pyrrole in place of 1,2,4-triazole as the nucleophile. 1H NMR (300 MHz, CDCl3) δ 8.47 (d, 1H, J=1.21 Hz), 7.75 (d, 1H, J=1.20 Hz), 7.27 (d, 1H, J=8.60 Hz), 7.18 (d, 1H, J=8.66 Hz), 7.05 (s, 2H, benzoyl Hs), 3.94 (s, 3H, OMe), 3.74 (s, 6H, 2×OMe), 3.73 (s, 3H, OMe).

Sources & evidence

ORD record
ord-a55437a7509b41da99d1659b29ffa5d2
Source dataset
uspto-grants-2013_10
Patent number
US08557982B2

Reaction notes

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