反应详情

To a solution of N-(3-(dimethylamino)propyl)-N-methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine (246 mg, 0.8 mmol) in EtOH was added Raney Nickel (700 mg, wet, washed). The reaction was allowed to stir for 2 h then filtered through a pad of Celite and concentrated under reduced pressure to afford N2-(3-(dimethylamino)propyl)-N2-methyl-5-(trifluoromethyl)pyridine-2,3-diamine. MS m/z=277 [M+H]+. Calc'd for C12H19F3N4: 276

1. filtrationthen filtered through a pad of Celite
2. concentrationconcentrated under reduced pressure