HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-(dimethylamino)propyl)-N-methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine → N2-(3-(dimethylamino)propyl)-N2-methyl-5-(trifluoromethyl)pyridine-2,3-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-(dimethylamino)propyl)-N-methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine | HCID 68460853 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N2-(3-(dimethylamino)propyl)-N2-methyl-5-(trifluoromethyl)pyridine-2,3-diamine | HCID 59427941 | — |
Reaction Steps
To a solution of N-(3-(dimethylamino)propyl)-N-methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine (246 mg, 0.8 mmol) in EtOH was added Raney Nickel (700 mg, wet, washed). The reaction was allowed to stir for 2 h then filtered through a pad of Celite and concentrated under reduced pressure to afford N2-(3-(dimethylamino)propyl)-N2-methyl-5-(trifluoromethyl)pyridine-2,3-diamine. MS m/z=277 [M+H]+. Calc'd for C12H19F3N4: 276
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557996B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-b28428ee9f214437b58045aa602c1666 |
| Source note | uspto-grants-2013_10 |