3-Amino-2-fluorobenzotrifluoride → 3-Bromo-4-chloro-N-(2-fluoro-3-(trifluoromethyl)phenyl)benzamide

HRID 1042733Notes

Reaction equation

HRID 1042733 reaction equation
[F:1][C:2]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[Br:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[Cl:23])[C:17](Cl)=[O:18]>>[Br:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[Cl:23])[C:17]([NH:4][C:3]1[CH:5]=[CH:6][CH:7]=[C:8]([C:9]([F:10])([F:11])[F:12])[C:2]=1[F:1])=[O:18]

Participants

3

Reactant 2

HCID 1455693-Amino-2-fluorobenzotrifluorideHCID 202297303-Bromo-4-chlorobenzoyl chloride

Product 1

HCID 594280393-Bromo-4-chloro-N-(2-fluoro-3-(trifluoromethyl)phenyl)benzamide

Procedure

3-Bromo-4-chloro-N-(2-fluoro-3-(trifluoromethyl)phenyl)benzamide was synthesized from 2-fluoro-3-(trifluromethyl)aniline and 3-bromo-4-chlorobenzoyl chloride according to the procedure described in Example 183. 3-Bromo-4-chloro-N-(2-fluoro-3-(trifluoromethyl)phenyl)benzamide was obtained as a red-orange solid. MS (M−H+) 393.9; Calc'd for C14H7BrClF4NO: 395.

Sources & evidence

ORD record
ord-ae10da11e87e4b10a4c215a42ce4aaf4
Source dataset
uspto-grants-2013_10
Patent number
US08557996B2

Reaction notes

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