反应详情

Ethyl 7-bromo-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate (1 g, 3 mmol) and 2.5 M NaOH (10 mL) were refluxed for 1 h in a RBF fitted with a reflux condenser. The hot, heterogeneous mixture was diluted with boiling water at which point a tan precipitate dissolved. Charcoal was added to the solution, which was swirled for 2 min and then the mixture was filtered. Glacial acetic acid was added to the filtrate and a white precipitate started to form (pH adjusted to 4). The precipitate was filtered off upon cooling, washed with water and dried to provide the desired product as a white solid.

1. customfitted with a reflux condenser
2. dissolutiondissolved
3. filtrationthe mixture was filtered
4. additionGlacial acetic acid was added to the filtrate
5. customto form (pH adjusted to 4)
6. filtrationThe precipitate was filtered off
7. temperatureupon cooling
8. washwashed with water
9. customdried