Hexane → HCID 178516446, compound

HRID 1042846Notes

Reaction equation

HRID 1042846 reaction equation
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)C(=O)O1.CCCCCC>C1(OC2C=CC=CC=2)C=CC=CC=1>[N:10]1[C:11]2[C:12](=[CH:13][N:14]=[CH:15][CH:16]=2)[C:6]([OH:8])=[CH:5][CH:9]=1

Participants

4

Reactant 2

HCID 8058HexaneHCID 59427333HCID 59427333, compound

Product 1

HCID 178516446HCID 178516446, compound

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

A solution of 2,2-dimethyl-5-((pyridin-4-ylamino)methylene)-1,3-dioxane-4,6-dione (1.149 g, 4.63 mmol) in diphenyl ether was heated at 200° C. for 20 min, then cooled to RT. Hexane was added and the mixture was stirred at RT for 30 mins. The solid was filtered off and washed with hexane to furnish 1,6-naphthyridin-4-ol as an off-brown solid.

Workup

  1. filtrationThe solid was filtered off
  2. washwashed with hexane

Sources & evidence

ORD record
ord-953f7361ca1e44479d026f55ba6dd1e9
Source dataset
uspto-grants-2013_10
Patent number
US08557816B2

Reaction notes

Loading…