Hexane → HCID 178493398, compound

HRID 1042849Notes

Reaction equation

HRID 1042849 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][CH:12]=[C:13]2[C:18](=[O:19])OC(C)(C)OC2=O)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.CCCCCC>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[CH:4]=[C:5]2[C:6]=1[C:18]([OH:19])=[CH:13][CH:12]=[N:11]2

Participants

4

Reactant 2

HCID 8058HexaneHCID 673176235-(((3,5-Dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 178493398HCID 178493398, compound

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

A solution of 5-((3,5-dimethoxyphenylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (9.23 g, 30.0 mmol) in diphenyl ether was heated at 200° C. for 20 min., then cooled down to RT. Hexane was added and the mixture was stirred at RT for 30 mins. The solvent was removed to furnish 5,7-dimethoxyquinolin-4-ol as a light brown solid, which was used for next step without further purification. MS Found m/z=[M+H]+. 206.2 Calc'd for C11H11NO3: 205.2.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-578bd712be684cbcb5ce209e4f5bb51e
Source dataset
uspto-grants-2013_10
Patent number
US08557816B2

Reaction notes

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