Hydrochloric Acid → HCID 178526855, compound

Participants

Reaction Steps

65.8 g of 2,4-Dinitroimidazole wetted with chlorobenzene (wetted with 31 mass % of chlorobenzene) was added to 660 mL of 35 mass % of hydrochloric acid and the temperature of the reaction liquid was elevated to 100° C. and reacted for 5 hours. After the reaction ended, the solution was cooled for crystallization. After the crystals were filtered, the crystals were heated and dissolved in 930 mL of water at 90° C. and 33.0 g of 2-chloro-4-nitroimidazole (yield 70.7%) (HPLC purity 97.6%) was obtained by cooling, filtration and drying. This was identified to be 2-chloro-4-nitroimidazole by

Provenance & Evidence