Hydrochloric Acid → HCID 178526855, compound

HRID 1042952Notes

Reaction equation

HRID 1042952 reaction equation
[N+]([C:4]1[NH:5][CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[N:8]=1)([O-])=O.[ClH:12]>ClC1C=CC=CC=1>[Cl:12][C:4]1[NH:5][CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[N:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178526857HCID 178526857, compound

Product 1

HCID 178526855HCID 178526855, compoundYield 70.7%

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

65.8 g of 2,4-Dinitroimidazole wetted with chlorobenzene (wetted with 31 mass % of chlorobenzene) was added to 660 mL of 35 mass % of hydrochloric acid and the temperature of the reaction liquid was elevated to 100° C. and reacted for 5 hours. After the reaction ended, the solution was cooled for crystallization. After the crystals were filtered, the crystals were heated and dissolved in 930 mL of water at 90° C. and 33.0 g of 2-chloro-4-nitroimidazole (yield 70.7%) (HPLC purity 97.6%) was obtained by cooling, filtration and drying. This was identified to be 2-chloro-4-nitroimidazole by

Workup

  1. customthe temperature of the reaction liquid
  2. customwas elevated to 100° C.
  3. customreacted for 5 hours
  4. temperaturethe solution was cooled for crystallization
  5. filtrationAfter the crystals were filtered
  6. temperaturethe crystals were heated
  7. dissolutiondissolved in 930 mL of water at 90° C.

Sources & evidence

ORD record
ord-84ac57850aac4a86af5087b2fcb90c84
Source dataset
uspto-grants-2013_10
Patent number
US08558005B2

Reaction notes

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