Hydrochloric Acid → HCID 178526855, compound

HRID 1042955Notes

Reaction equation

HRID 1042955 reaction equation
[N+]([C:4]1[NH:5][CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[N:8]=1)([O-])=O.[ClH:12]>>[Cl:12][C:4]1[NH:5][CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[N:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178526857HCID 178526857, compound

Product 1

HCID 178526855HCID 178526855, compoundYield 67.1%

Conditions

Temperature
95 °C

Procedure

5.0 g of 2,4-dinitroimidazole (purity 92.3%) was added to 62 mL of 35 mass % hydrochloric acid. The reaction liquid was warmed to 95° C. and the reaction was performed for 7 hours. After the reaction, the reaction mixture was cooled to 0° C. for crystallization. The crystals were filtered and dried to obtain 2.88 g of 2-chloro-4-nitroimidazole (yield 67.1%).

Workup

  1. customThe reaction liquid
  2. customAfter the reaction
  3. temperaturethe reaction mixture was cooled to 0° C. for crystallization
  4. filtrationThe crystals were filtered
  5. customdried

Sources & evidence

ORD record
ord-d6ba4e9172954800a53f9e714e348f4f
Source dataset
uspto-grants-2013_10
Patent number
US08558005B2

Reaction notes

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