Ethanol → 3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol

To a mixture of 3-(methylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride (10.3 g, 50 mmol) and ethanol (35 mL) at 4° C. sodium hydroxide (4.0 g of a 50% aqueous solution) was added in about 5 minutes. Afterwards, neat sodium borhydride (0.95 g, 25 mmol, 1.0 eq) was added in several portions in about 30 minutes. At the end of the addition, the suspension was stirred for 4 h at the same temperature, then acetone (10.0 mL) was added dropwise in 5 minutes and the mixture was stirred for 10 additional minutes. Water (20 mL) was then added. Afterwards, the mixture was concentrated about 5 times under vacuum and the residue was extracted with tert-butyl methyl ether (2×20 mL). The collected organic phases were finally concentrated under vacuum affording an orange oil which crystallised spontaneously after a few hours. Finally, an orange solid was obtained (7.2 g, 84% yield). This compound can then be used without further purification.

1. additionwas added in about 5 minutes
2. additionAt the end of the addition
3. stirringthe mixture was stirred for 10 additional minutes
4. concentrationAfterwards, the mixture was concentrated about 5 times under vacuum
5. extractionthe residue was extracted with tert-butyl methyl ether (2×20 mL)
6. concentrationThe collected organic phases were finally concentrated under vacuum
7. customaffording an orange oil which
8. customcrystallised spontaneously after a few hours
9. customFinally, an orange solid was obtained (7.2 g, 84% yield)
10. customThis compound can then be used without further purification

ORD record

ord-166996995c1e4d049a8c8fa865be6c73

Source dataset

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08558014B2