Triethylamine → racemic 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[1-(2-pyridinyl)ethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

HRID 1043016Notes

Reaction equation

HRID 1043016 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([NH:18][C@@H:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=4)[CH3:20])=[C:12]([NH2:17])[CH:13]=[N:14]3)=[CH:9][C:8]=2[O:27][CH3:28])=[C:5]([CH3:29])[O:4][N:3]=1.[O:30]1[CH2:35][CH2:34][CH:33]([C:36](O)=O)[CH2:32][CH2:31]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)CC)C.C(=O)([O-])O.[Na+]>C(Cl)Cl>[CH3:1][C:2]1[C:6]([C:7]2[C:8]([O:27][CH3:28])=[CH:9][C:10]3[C:11]4[N:18]([CH:19]([C:21]5[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=5)[CH3:20])[C:36]([CH:33]5[CH2:34][CH2:35][O:30][CH2:31][CH2:32]5)=[N:17][C:12]=4[CH:13]=[N:14][C:15]=3[CH:16]=2)=[C:5]([CH3:29])[O:4][N:3]=1

Participants

7

Reactant 5

HCID 8471TriethylamineHCID 219302Oxane-4-carboxylic acidHCID 516892Sodium BicarbonateHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 672077397-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-N4-[(1R)-1-(2-pyridinyl)ethyl]-3,4-quinolinediamine2×

Product 1

HCID 57465603racemic 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[1-(2-pyridinyl)ethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-N4-[(1R)-1-(2-pyridinyl)ethyl]-3,4-quinolinediamine (for a preparation see Intermediate 64, 380 mg) in DCM (20 ml) was added tetrahydro-2H-pyran-4-carboxylic acid (240 mg) followed by HATU (1.2 equiv) and triethylamine (1.5 equiv). The reaction mixture was stirred at room temperature for 1 h, and then hydrolysed using a saturated solution of sodium hydrogen carbonate. The mixture was extracted with DCM and the organic was dried over Na2SO4, filtered and concentrated to dryness. The resulting crude product was diluted in acetic acid (5 ml) and heated at 100° C. overnight. The reaction mixture was then taken-up in a 1:1 mixture of sodium hydroxide (1N) and water (total 100 ml), extracted with DCM and the resulting crude product was purified by chromatography on silica gel eluting with DCM/methanol (95:5). The resulting product was taken-up in diethyl ether and dried under vacuum to give racemic 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[1-(2-pyridinyl)ethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline (400 mg) as a grey powder.

Workup

  1. extractionThe mixture was extracted with DCM
  2. dry with materialthe organic was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated to dryness
  5. additionThe resulting crude product was diluted in acetic acid (5 ml)
  6. temperatureheated at 100° C. overnight
  7. additiontaken-up in a 1:1 mixture of sodium hydroxide (1N) and water (total 100 ml)
  8. extractionextracted with DCM
  9. customthe resulting crude product was purified by chromatography on silica gel eluting with DCM/methanol (95:5)
  10. customdried under vacuum

Sources & evidence

ORD record
ord-28584c3aaf4842eeaca8646734a66105
Source dataset
uspto-grants-2013_10
Patent number
US08557984B2

Reaction notes

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