Trifluoroacetic acid → HCID 178511287, compound

HRID 1043193Notes

Reaction equation

HRID 1043193 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH2:8][NH:9]C(=O)OC(C)(C)C)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>ClCCl>[NH2:9][CH2:8][C@H:5]1[CH2:6][CH2:7][C@H:2]([OH:1])[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453650HCID 178453650, compound

Product 1

HCID 178511287HCID 178511287, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl trans-(4-hydroxycyclohexyl)methylcarbamate (1 g) in dichloromethane (10 ml) was treated with trifluoroacetic acid (10 ml) at 0° C. for two hours. The reaction mixture was concentrated and the residue was dried under vacuum to provide the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-4ed8e723af814e3db225f0828ed54856
Source dataset
uspto-grants-2013_10
Patent number
US08557983B2

Reaction notes

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