反应详情

温度

120 °C

9.30 g of 6-chloro-1H,3H-benzo[de]isochromene-1,3-dione and 4.46 g of hydrochlorided cystamine hydrochloride are suspended in 50 ml of N-methylpyrrolidone (NMP). 5.5 g of diisopropylethylamine are added and the mixture is heated with stirring at 120° C. After two hours, 50 ml of NMP are added and the mixture is kept with stirring at 120° C. for 3 hours. After cooling, the precipitated product is recovered and the filtered solution is extended by addition of 200 ml of water, and a second precipitate is recovered. The precipitates are washed with water and dried. 11.46 g of white powder are recovered. The analyses show that the product is in accordance with the expected product.

1. temperaturethe mixture is heated
2. stirringwith stirring at 120° C. for 3 hours
3. temperatureAfter cooling
4. customthe precipitated product is recovered
5. additionthe filtered solution is extended by addition of 200 ml of water
6. customa second precipitate is recovered
7. washThe precipitates are washed with water
8. customdried
9. custom11.46 g of white powder are recovered