反应详情

To a solution of the material from Step 1 (2.4 g, 8.9 mmol) in 30 mL of THF at −78° C. was added LiAlH4 (337 mg, 8.9 mmol). The mixture was stirred at or below −60° C. for 2 hr, and then stirred at room temperature for 1 hr. The reaction was quenched with 10% NaOH (aq) solution, and the mixture was extracted with EtOAc. The organic layer was separated, dried over MgSO4, and concentrated to get 2-(4-bromophenyl)-2-methylpropan-1-ol (2.03 g, 100%).

1. stirringstirred at room temperature for 1 hr
2. customThe reaction was quenched with 10% NaOH (aq) solution
3. extractionthe mixture was extracted with EtOAc
4. customThe organic layer was separated
5. dry with materialdried over MgSO4
6. concentrationconcentrated