Hydrochloric Acid → 4-[4-(Trifluoromethoxy)phenoxy]piperidine

HRID 1043527Notes

Reaction equation

HRID 1043527 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[F:25][C:22]([F:23])([F:24])[O:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23081100tert-Butyl 4-[4-(trifluoromethoxy)phenoxy]piperidine-1-carboxylate

Product 1

HCID 161154394-[4-(Trifluoromethoxy)phenoxy]piperidineYield 115%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4-(4-(trifluoromethoxy)phenoxy)piperidine-1-formic acid tert-butyl ester (2.5 g, 6.66 mmol) was dissolved in 1,4-dioxane, added dropwise hydrogen chloride in 1,4-dioxane solution, stirred for 3 h at room temperature, removed solvents after the reaction was completed, residuals were washed by petroleum ether and ethyl ether respectively to give 2.0 g white solid, yield was 99%.

Workup

  1. customremoved solvents after the reaction
  2. washresiduals were washed by petroleum ether and ethyl ether respectively

Sources & evidence

ORD record
ord-4ace071c3e634bcc8d8bdde2bd3b6e7b
Source dataset
uspto-grants-2013_10
Patent number
US08563547B2

Reaction notes

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