反应详情

4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester (1.73 g, 5 mmol) was dissolved in methanol (15 mL), added HCl/MeOH saturated solution (15 mL), stirred for 3 h at room temperature, removed solvents under reduced pressure, residuals were washed by ethyl ether to give 1.4 g white solid, ie 4-(4-(trifluoromethoxy)phenyl)piperidine hydrochloride, yield was 100%.

1. customremoved solvents under reduced pressure, residuals
2. washwere washed by ethyl ether