Hydrochloride methanol → 4-(4-(Trifluoromethoxy)phenyl)piperidine

HRID 1043530Notes

Reaction equation

HRID 1043530 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.CO>CO>[F:24][C:21]([F:22])([F:23])[O:20][C:17]1[CH:18]=[CH:19][C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 57666893Tert-butyl 4-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxylate

Product 1

HCID 212682884-(4-(Trifluoromethoxy)phenyl)piperidineYield 114.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester (1.73 g, 5 mmol) was dissolved in methanol (15 mL), added HCl/MeOH saturated solution (15 mL), stirred for 3 h at room temperature, removed solvents under reduced pressure, residuals were washed by ethyl ether to give 1.4 g white solid, ie 4-(4-(trifluoromethoxy)phenyl)piperidine hydrochloride, yield was 100%.

Workup

  1. customremoved solvents under reduced pressure, residuals
  2. washwere washed by ethyl ether

Sources & evidence

ORD record
ord-14a76f61cfe44e3ea5cffbbbdb00cbb8
Source dataset
uspto-grants-2013_10
Patent number
US08563547B2

Reaction notes

Loading…