HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → 4-(4-(Trifluoromethoxy)phenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | Tert-butyl 4-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxylate | HCID 57666893 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(4-(Trifluoromethoxy)phenyl)piperidine | HCID 21268288 | 114.2% |
Reaction Steps
4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester (1.73 g, 5 mmol) was dissolved in methanol (15 mL), added HCl/MeOH saturated solution (15 mL), stirred for 3 h at room temperature, removed solvents under reduced pressure, residuals were washed by ethyl ether to give 1.4 g white solid, ie 4-(4-(trifluoromethoxy)phenyl)piperidine hydrochloride, yield was 100%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563547B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-14a76f61cfe44e3ea5cffbbbdb00cbb8 |
| Source note | uspto-grants-2013_10 |