反应详情

温度

0 °C

4-(4-(trifluoromethoxy)phenoxy)piperidine (1.31 g, 5.0 mmol) was dissolved in dry dichloromethane (30 mL), cooled to 0° C. in ice salt-bath, added ethylene oxide (2.55 mL, 50 mmol), reacted for 3 h in ice salt-bath, stopped the reaction, the reaction was monitored by TLC, the system was spun dry after complete reaction to give 1.52 g title compound, yield was 100%.

1. customreacted for 3 h in ice salt-bath
2. customthe reaction
3. customthe system was spun dry
4. customafter complete reaction