Ethylene Oxide → HCID 68207020, compound

Participants

Reaction Conditions

Reaction Steps

4-(4-(trifluoromethoxy)phenoxy)piperidine (1.31 g, 5.0 mmol) was dissolved in dry dichloromethane (30 mL), cooled to 0° C. in ice salt-bath, added ethylene oxide (2.55 mL, 50 mmol), reacted for 3 h in ice salt-bath, stopped the reaction, the reaction was monitored by TLC, the system was spun dry after complete reaction to give 1.52 g title compound, yield was 100%.

Provenance & Evidence