反应详情

3-(3-(4-(trifluoromethoxy)phenoxy)azetidin-1-yl)propionic acid (400 mg, 1.31 mmol) was dissolved in thionyl chloride, raised the temperature to reflux for 3 h, spun dry, residuals were washed by an appropriate amount of ethyl ether, generated 423 mg target product, yield was 100%, directly put to the next reaction step.

1. temperatureraised the temperature
2. temperatureto reflux for 3 h
3. customspun dry
4. washresiduals were washed by an appropriate amount of ethyl ether
5. customdirectly put to the next reaction step