HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(3-(4-(Trifluoromethoxy)phenoxy)azetidin-1-yl)propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(3-(4-(Trifluoromethoxy)phenoxy)azetidin-1-yl)propionic acid | HCID 86685904 | — |
| Product | 3-(3-(4-(Trifluoromethoxy)phenoxy)azetidin-1-yl)propionyl chloride | HCID 86685903 | 100% |
Reaction Steps
3-(3-(4-(trifluoromethoxy)phenoxy)azetidin-1-yl)propionic acid (400 mg, 1.31 mmol) was dissolved in thionyl chloride, raised the temperature to reflux for 3 h, spun dry, residuals were washed by an appropriate amount of ethyl ether, generated 423 mg target product, yield was 100%, directly put to the next reaction step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563547B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-9042d2087b6749eca426f18487e69e36 |
| Source note | uspto-grants-2013_10 |