2-Methyl-2-(piperazin-1-yl)propanamide → 2-(4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide

HRID 1043588Notes

Reaction equation

HRID 1043588 reaction equation
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]=[C:8]([Cl:19])[N:9]=[C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[C:11]=2[N:12]=1.[CH3:20][C:21]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)([CH3:25])[C:22]([NH2:24])=[O:23]>>[Cl:19][C:8]1[N:9]=[C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:11]2[N:12]=[C:3]([CH2:2][N:29]3[CH2:28][CH2:27][N:26]([C:21]([CH3:25])([CH3:20])[C:22]([NH2:24])=[O:23])[CH2:31][CH2:30]3)[CH:4]=[CH:5][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 217488412-Methyl-2-(piperazin-1-yl)propanamideHCID 584049784-(6-(Bromomethyl)-2-chloropyrido[3,2-D]pyrimidin-4-YL)morpholine

Product 1

HCID 584049422-(4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide

Procedure

4-(6-(Bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine 7 (0.1 g) was reacted with 2-methyl-2-(piperazin-1-yl)propanamide via General Procedure B to give 123 mg of 2-(4-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide.

Sources & evidence

ORD record
ord-ad29921853eb42e6a7d9d7874f1ca929
Source dataset
uspto-grants-2013_10
Patent number
US08563540B2

Reaction notes

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