HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-Aminopyridin-3-yl)boronic acid → 2-(4-((2-(6-Aminopyridin-3-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-Aminopyridin-3-yl)boronic acid | HCID 22396308 | — |
| Reactant | 2-(4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide | HCID 58404942 | — |
| Product | 2-(4-((2-(6-Aminopyridin-3-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide | HCID 53378468 | — |
Reaction Steps
2-(4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide from Example 121 (115 mg) was reacted with 2-aminopyridine-5-boronic acid, pinacol ester via General Procedure A to yield 8.5 mg 124 following reverse phase HPLC purification. MS (Q1) 492.3 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563540B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-06d15d18f6734c198cda158edda42df7 |
| Source note | uspto-grants-2013_10 |