反应详情

温度

80 °C

The starting 2-bromo-imidazo[2,1-b][1,3,4]thiadiazole (2.0 g; 9.9 mmol) was dissolved in oleum (4.0 mL) and the resulting solution was heated at 80° C. for 8 hours. The reaction was allowed to cool to room temperature and then poured onto crushed ice. One spoon of sodium chloride was added and the resulting precipitate was isolated by vacuum filtration and washed with cold water. It was dried by azeotrope distillation with toluene. The title compound 2-bromo-imidazo[2,1-b][1,3,4]thiadiazole-5-sulfonic acid was isolated as a beige solid, (2.33 g; 83% yield).

1. temperatureto cool to room temperature
2. additionpoured
3. customonto crushed ice
4. customthe resulting precipitate was isolated by vacuum filtration
5. washwashed with cold water
6. dry with materialIt was dried by azeotrope distillation with toluene