2-Chloro-4,6-dimethylpyrimidine → HCID 66859781, compound

HRID 1043692Notes

Reaction equation

HRID 1043692 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][CH:11]1[CH2:16][CH:15]([CH3:17])[CH2:14][NH:13][CH2:12]1.ClC1N=CC=CN=1.CC1OC(C)CNC1>>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[N:7]=[C:2]([N:13]2[CH2:14][CH:15]([CH3:17])[CH2:16][CH:11]([CH3:10])[CH2:12]2)[N:3]=1

Participants

5

Reactant 4

HCID 205502-Chloro-4,6-dimethylpyrimidineHCID 744042-ChloropyrimidineHCID 1108622,6-DimethylmorpholineHCID 1182593,5-Dimethylpiperidine

Product 1

HCID 66859781HCID 66859781, compound

Procedure

In a similar manner to Synthesis Example 6-1 except that 2-chloro-4,6-dimethylpyrimidine and 3,5-dimethylpiperidine were used instead of 2-chloropyrimidine and 2,6-dimethylmorpholine, respectively, N-(4,6-dimethylpyrimidin-2-yl)-3,5-dimethylpiperidine (Compound 45) was obtained (yield 97%).

Sources & evidence

ORD record
ord-1b073fa44aa7477296ae1bd68f603f38
Source dataset
uspto-grants-2013_10
Patent number
US08563552B2

Reaction notes

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