Lactic Acid → HCID 178473660, compound

HRID 1043693Notes

Reaction equation

HRID 1043693 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[F:12])[NH:5][C:4](=[O:13])[C:3]=1[C:14]1[NH:18][C:17]2[CH:19]=[CH:20][C:21]([N:23]3[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]3)=[CH:22][C:16]=2[N:15]=1.Cl(O)(=O)(=O)=O.[C:35]([OH:40])(=[O:39])[CH:36]([CH3:38])[OH:37]>O>[C:35]([OH:40])(=[O:39])[CH:36]([CH3:38])[OH:37].[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[F:12])[NH:5][C:4](=[O:13])[C:3]=1[C:14]1[NH:18][C:17]2[CH:19]=[CH:20][C:21]([N:23]3[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]3)=[CH:22][C:16]=2[N:15]=1

Participants

5

Reactant 3

HCID 612Lactic Acid2×HCID 24247Perchloric AcidHCID 178480639HCID 178480639, compound

Product 1

HCID 178473660HCID 178473660, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Titration of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one by perchloric acid and titration of the lactic acid shows the stoichiometry 1:1 of the base and lactic acid. Thermogravimetry water <0.5%, purity HPLC>99.5%.

Sources & evidence

ORD record
ord-da5136b85a2a4268802629ff5b3e778a
Source dataset
uspto-grants-2013_10
Patent number
US08563556B2

Reaction notes

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