反应详情

A solution containing N-benzyl piperidone 1 (5 g, 26.4 mmol) and pyrrolidine 2 (2.82 g, 39.6 mmol) in toluene (60 mL) was heated to reflux with azeotropic removal of water. The reaction mixture was then cooled and concentrated under reduced pressure. The resulting oil was dissolved in ether, dried over magnesium sulfate, and concentrated under reduced pressure. The crude enamine 3 was used in the next step.

1. temperaturewas heated
2. temperatureThe reaction mixture was then cooled
3. concentrationconcentrated under reduced pressure
4. dissolutionThe resulting oil was dissolved in ether
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure