反应详情

温度

40 °C

To a solution of 5 (500 mg, 1.7 mmol) in dichoromethane (8 mL) was added compound 6, 3-chloro propionyl chloride (0.22 mL, 2.1 mmol) and the reaction mixture was stirred at 40° C. for 18 h. The reaction was then cooled to room temperature and concentrated. The resulting residue was dissolved in methanol (16 mL) and stirred at 40° C. for 3 h. The mixture was then cooled to room temperature and concentrated.

1. temperatureThe reaction was then cooled to room temperature
2. concentrationconcentrated
3. dissolutionThe resulting residue was dissolved in methanol (16 mL)
4. stirringstirred at 40° C. for 3 h
5. temperatureThe mixture was then cooled to room temperature
6. concentrationconcentrated